Management Team
Dr. Pad Chivukula is the co-founder of Arcturus Therapeutics and has served as the Chief Scientific Officer and Chief Operating Officer since 2013. With a deep foundation in nanoparticle technology, Dr. Chivukula leads Arcturus in discovering and developing transformative medicines for diseases with unmet needs. Since Arcturus’ founding, he has built and advanced the company’s research competencies and pipeline in the areas of RNA therapeutics and vaccines, integrating advanced therapeutic platforms, and streamlining innovative processes. Dr. Chivukula holds over 100 publications and patents.
Prior to Arcturus, Dr. Chivukula held key roles at Nitto, including Group Leader and Chief Scientist, where he led the polymeric RNAi research department. He holds a Ph.D. in Pharmaceutical Chemistry from the University of Utah, specializing in nanoparticle technology.
Alan H. Cohen, MD, is a board-certified Pediatric Pulmonologist with a longstanding interest in cardio-respiratory illnesses. He has been clinically active for the balance of his 35+ years of practice, with a focus on caring for people with Cystic Fibrosis, as well as previously co-directing the largest and most active pediatric lung transplantation program in North America. He has served on the faculty of many highly regarded Pulmonary Centers of Excellence, including those at the University of Colorado/National Jewish Center for Immunology & Respiratory Diseases, where he also was a resident and fellow, Washington University School of Medicine, Johns Hopkins and most recently at Stanford University School of Medicine.
In addition to his many years of clinical practice, biomedical and basic science research, and teaching, he has dedicated over 25 of his 35+ year-long professional career to drug discovery, in the Biotech & Pharma clinical/medical research space, at both small, entrepreneurial pre-IPO start-ups, as well as more well-established public companies worldwide. He has most recently worked in the fields of heart failure (amyloid-related) and pulmonary hypertension, respiratory infectious diseases (P aeruginosa, influenza and RSV), as well as gene editing/gene therapy targeting monogenetically driven conditions, including rare and more common diseases such as alpha-1 antitrypsin deficiency, amyloidosis, cystic fibrosis, hemophilia and Fabry Disease.
His research and drug development career have included roles of increasing responsibility and leadership at companies such as: 4D Molecular Therapeutics (SVP/TAH Pulmonary, CV & Rare Diseases), Metagenomi (SVP/CMO Clin Dev Gene Editing), Eidos/BridgeBio (VP), Bayer (GCL), Aridis Pharma (SVP), Therabron Therapeutics (SVP/CMO), Eddingpharm (CMO), Boehringer Ingelheim, InterMune (SVP - acquired by Roche / Genentech), MAP Pharma (VP - acquired by Allergan), Jazz Pharma (CMO/VP) & Medimmune (acquired Astra Zeneca).
Dr. Cohen has remained clinically active throughout his professional medical career, including direct patient care as well as teaching medical students, residents and fellows, most recently serving as adjunct clinical and teaching faculty at Stanford University School of Medicine – in the Dept. of Pediatric Pulmonology.
Ye Zhang is the Chief Regulatory Officer for Arcturus Therapeutics, where she establishes Regulatory Affairs department and oversees the Regulatory Strategy, Regulatory CMC, Regulatory Operation and Labeling to support the development of vaccines and rare disease therapeutics. Under her leadership, the team successfully supported the COVID-19 Vaccine NDA filing with the PMDA, leading to Arcturus' first drug product approval and the world's inaugural approval of a self-amplifying mRNA vaccine. Dr. Zhang has more than 20 years of experience in regulatory and drug development for vaccines, biologics and small molecules. Prior to joining Arcturus Therapeutics, Dr. Zhang held various roles of increasing responsibility at Merck, where she was responsible for more than ten vaccines in development and life-cycle management and had extensive experience in working with FDA, EMA, PMDA, MHRA, NMPA and other regulatory authorities. She also worked at FDA where she reviewed more than 60 drug applications and gained extensive regulatory experience. Dr. Zhang received a Ph.D. in Pharmaceutical Sciences from the University of Colorado, and an M.D. from the Medical School of Peking University. Dr. Zhang is a lifetime member of the Food and Drug Administration Alumni Association (FDAAA) and serves as a board director for Alliance for mRNA Medicine (AMM). Recognized for her achievements, she was named as one of the Top 25 Healthcare Technology Leaders of Pennsylvania for 2023.
Before joining Arcturus, Dr. Smolenov was the Executive Vice President at Clover Pharmaceuticals, where he built a strong team able to rapidly generate pivotal clinical data leading to COVID-19 vaccine authorization and the product launch. Before that, Dr. Smolenov served as Therapeutic Area Head, leading the development of several seasonal influenza vaccines in Seqirus (CSL), and Head of Clinical Development in Moderna Therapeutics, managing the initiation of the first clinical trials of mRNA vaccines in humans. At Novartis Vaccines, Dr. Smolenov contributed to the development and global licensure of meningococcal vaccines (Menveo®, Bexsero®, and MenABCWY) and the overall commercial success of the meningococcal vaccines franchise.
Igor Smolenov graduated from Volgograd State Medical University, Russia, and holds MD, Ph.D., and Doctor of Science (D.Sc.) (Habilitation) degrees from this university. Before starting his industry career, he passed multiple academic steps from junior researcher to professor and head of the Allergy/immunology department of the university. He is the author of more than 50 publications in peer-reviewed journals in clinical pharmacology, infectious diseases, and vaccine development.